RapamycinFungusV1, Main, Exploration, bibRecord, 001174

Induction of biogenic magnetization and redox control by a component of the target of rapamycin complex 1 signaling pathway.

Identifieur interne : 001174 ( Main/Exploration ); précédent : 001173; suivant : 001175

Induction of biogenic magnetization and redox control by a component of the target of rapamycin complex 1 signaling pathway.

Auteurs : Keiji Nishida [États-Unis] ; Pamela A. Silver

Source :

PLoS biology [ 1545-7885 ] ; 2012.

RBID : pubmed:22389629

Descripteurs français

English descriptors

KwdEn :
- Cation Transport Proteins (metabolism), Ferric Compounds (metabolism), Ferritins (biosynthesis), Gene Dosage (MeSH), Gene Knockout Techniques (MeSH), Humans (MeSH), Iron-Binding Proteins (genetics), Iron-Binding Proteins (metabolism), Magnetic Phenomena (MeSH), Magnetometry (MeSH), Mitochondria (enzymology), Mitochondria (metabolism), Mitochondrial Proteins (genetics), Mitochondrial Proteins (metabolism), NADP (metabolism), Organisms, Genetically Modified (MeSH), Oxidation-Reduction (MeSH), Phosphotransferases (Alcohol Group Acceptor) (genetics), Phosphotransferases (Alcohol Group Acceptor) (metabolism), Protein-Serine-Threonine Kinases (genetics), Protein-Serine-Threonine Kinases (metabolism), Recombinant Proteins (biosynthesis), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae (ultrastructure), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Transcription Factors (metabolism).
MESH :
- chemical , biosynthesis : Ferritins, Recombinant Proteins.
- chemical , genetics : Iron-Binding Proteins, Mitochondrial Proteins, Phosphotransferases (Alcohol Group Acceptor), Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins.
- chemical , metabolism : Cation Transport Proteins, Ferric Compounds, Iron-Binding Proteins, Mitochondrial Proteins, NADP, Phosphotransferases (Alcohol Group Acceptor), Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins, Transcription Factors.
- enzymology : Mitochondria.
- genetics : Saccharomyces cerevisiae.
- metabolism : Mitochondria, Saccharomyces cerevisiae.
- ultrastructure : Saccharomyces cerevisiae.
- Gene Dosage, Gene Knockout Techniques, Humans, Magnetic Phenomena, Magnetometry, Organisms, Genetically Modified, Oxidation-Reduction.

Abstract

Most organisms are simply diamagnetic, while magnetotactic bacteria and migratory animals are among organisms that exploit magnetism. Biogenic magnetization not only is of fundamental interest, but also has industrial potential. However, the key factor(s) that enable biogenic magnetization in coordination with other cellular functions and metabolism remain unknown. To address the requirements for induction and the application of synthetic bio-magnetism, we explored the creation of magnetism in a simple model organism. Cell magnetization was first observed by attraction towards a magnet when normally diamagnetic yeast Saccharomyces cerevisiae were grown with ferric citrate. The magnetization was further enhanced by genetic modification of iron homeostasis and introduction of ferritin. The acquired magnetizable properties enabled the cells to be attracted to a magnet, and be trapped by a magnetic column. Superconducting quantum interference device (SQUID) magnetometry confirmed and quantitatively characterized the acquired paramagnetism. Electron microscopy and energy-dispersive X-ray spectroscopy showed electron-dense iron-containing aggregates within the magnetized cells. Magnetization-based screening of gene knockouts identified Tco89p, a component of TORC1 (Target of rapamycin complex 1), as important for magnetization; loss of TCO89 and treatment with rapamycin reduced magnetization in a TCO89-dependent manner. The TCO89 expression level positively correlated with magnetization, enabling inducible magnetization. Several carbon metabolism genes were also shown to affect magnetization. Redox mediators indicated that TCO89 alters the intracellular redox to an oxidized state in a dose-dependent manner. Taken together, we demonstrated that synthetic induction of magnetization is possible and that the key factors are local redox control through carbon metabolism and iron supply.

DOI: 10.1371/journal.pbio.1001269
PubMed: 22389629
PubMed Central: PMC3289596

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<term>Gene Knockout Techniques (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Iron-Binding Proteins (genetics)</term>
<term>Iron-Binding Proteins (metabolism)</term>
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<term>Mitochondrial Proteins (genetics)</term>
<term>Mitochondrial Proteins (metabolism)</term>
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<term>Organisms, Genetically Modified (MeSH)</term>
<term>Oxidation-Reduction (MeSH)</term>
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<term>Phosphotransferases (Alcohol Group Acceptor) (metabolism)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Protein-Serine-Threonine Kinases (metabolism)</term>
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<term>Facteurs de transcription (métabolisme)</term>
<term>Ferritines (biosynthèse)</term>
<term>Humains (MeSH)</term>
<term>Magnétométrie (MeSH)</term>
<term>Mitochondries (enzymologie)</term>
<term>Mitochondries (métabolisme)</term>
<term>NADP (métabolisme)</term>
<term>Organismes génétiquement modifiés (MeSH)</term>
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<term>Phosphotransferases (Alcohol Group Acceptor) (génétique)</term>
<term>Phosphotransferases (Alcohol Group Acceptor) (métabolisme)</term>
<term>Phénomènes magnétiques (MeSH)</term>
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<term>Protein-Serine-Threonine Kinases (métabolisme)</term>
<term>Protéines de Saccharomyces cerevisiae (génétique)</term>
<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
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<term>Protéines de liaison au fer (métabolisme)</term>
<term>Protéines mitochondriales (génétique)</term>
<term>Protéines mitochondriales (métabolisme)</term>
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<term>Saccharomyces cerevisiae (métabolisme)</term>
<term>Saccharomyces cerevisiae (ultrastructure)</term>
<term>Techniques de knock-out de gènes (MeSH)</term>
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<term>Recombinant Proteins</term>
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<term>Mitochondrial Proteins</term>
<term>Phosphotransferases (Alcohol Group Acceptor)</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Saccharomyces cerevisiae Proteins</term>
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<term>Ferric Compounds</term>
<term>Iron-Binding Proteins</term>
<term>Mitochondrial Proteins</term>
<term>NADP</term>
<term>Phosphotransferases (Alcohol Group Acceptor)</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
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<term>Protéines recombinantes</term>
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<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Mitochondries</term>
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<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Protéines de liaison au fer</term>
<term>Protéines mitochondriales</term>
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<term>Facteurs de transcription</term>
<term>Mitochondries</term>
<term>NADP</term>
<term>Phosphotransferases (Alcohol Group Acceptor)</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines de Saccharomyces cerevisiae</term>
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<term>Gene Knockout Techniques</term>
<term>Humans</term>
<term>Magnetic Phenomena</term>
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<term>Humains</term>
<term>Magnétométrie</term>
<term>Organismes génétiquement modifiés</term>
<term>Oxydoréduction</term>
<term>Phénomènes magnétiques</term>
<term>Saccharomyces cerevisiae</term>
<term>Techniques de knock-out de gènes</term>
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<front><div type="abstract" xml:lang="en">Most organisms are simply diamagnetic, while magnetotactic bacteria and migratory animals are among organisms that exploit magnetism. Biogenic magnetization not only is of fundamental interest, but also has industrial potential. However, the key factor(s) that enable biogenic magnetization in coordination with other cellular functions and metabolism remain unknown. To address the requirements for induction and the application of synthetic bio-magnetism, we explored the creation of magnetism in a simple model organism. Cell magnetization was first observed by attraction towards a magnet when normally diamagnetic yeast Saccharomyces cerevisiae were grown with ferric citrate. The magnetization was further enhanced by genetic modification of iron homeostasis and introduction of ferritin. The acquired magnetizable properties enabled the cells to be attracted to a magnet, and be trapped by a magnetic column. Superconducting quantum interference device (SQUID) magnetometry confirmed and quantitatively characterized the acquired paramagnetism. Electron microscopy and energy-dispersive X-ray spectroscopy showed electron-dense iron-containing aggregates within the magnetized cells. Magnetization-based screening of gene knockouts identified Tco89p, a component of TORC1 (Target of rapamycin complex 1), as important for magnetization; loss of TCO89 and treatment with rapamycin reduced magnetization in a TCO89-dependent manner. The TCO89 expression level positively correlated with magnetization, enabling inducible magnetization. Several carbon metabolism genes were also shown to affect magnetization. Redox mediators indicated that TCO89 alters the intracellular redox to an oxidized state in a dose-dependent manner. Taken together, we demonstrated that synthetic induction of magnetization is possible and that the key factors are local redox control through carbon metabolism and iron supply.</div>
</front>
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<Abstract><AbstractText>Most organisms are simply diamagnetic, while magnetotactic bacteria and migratory animals are among organisms that exploit magnetism. Biogenic magnetization not only is of fundamental interest, but also has industrial potential. However, the key factor(s) that enable biogenic magnetization in coordination with other cellular functions and metabolism remain unknown. To address the requirements for induction and the application of synthetic bio-magnetism, we explored the creation of magnetism in a simple model organism. Cell magnetization was first observed by attraction towards a magnet when normally diamagnetic yeast Saccharomyces cerevisiae were grown with ferric citrate. The magnetization was further enhanced by genetic modification of iron homeostasis and introduction of ferritin. The acquired magnetizable properties enabled the cells to be attracted to a magnet, and be trapped by a magnetic column. Superconducting quantum interference device (SQUID) magnetometry confirmed and quantitatively characterized the acquired paramagnetism. Electron microscopy and energy-dispersive X-ray spectroscopy showed electron-dense iron-containing aggregates within the magnetized cells. Magnetization-based screening of gene knockouts identified Tco89p, a component of TORC1 (Target of rapamycin complex 1), as important for magnetization; loss of TCO89 and treatment with rapamycin reduced magnetization in a TCO89-dependent manner. The TCO89 expression level positively correlated with magnetization, enabling inducible magnetization. Several carbon metabolism genes were also shown to affect magnetization. Redox mediators indicated that TCO89 alters the intracellular redox to an oxidized state in a dose-dependent manner. Taken together, we demonstrated that synthetic induction of magnetization is possible and that the key factors are local redox control through carbon metabolism and iron supply.</AbstractText>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D027682" MajorTopicYN="N">Cation Transport Proteins</DescriptorName>
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<MeshHeading><DescriptorName UI="D005290" MajorTopicYN="N">Ferric Compounds</DescriptorName>
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<MeshHeading><DescriptorName UI="D033862" MajorTopicYN="N">Iron-Binding Proteins</DescriptorName>
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<CoiStatement>The authors have declared that no competing interests exist.</CoiStatement>
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	Serveur d'exploration sur la rapamycine et les champignons
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Induction of biogenic magnetization and redox control by a component of the target of rapamycin complex 1 signaling pathway.

Induction of biogenic magnetization and redox control by a component of the target of rapamycin complex 1 signaling pathway.

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